Selected Publications

Cellular Metabolism and Metabolic Regulation

2021

The metabolism of cancer cells during metastasis - Gabriele Bergers and Sarah-Maria Fendt - 2021 - Nature Reviews Cancer - PubMed

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition - Gianmarco Rinaldi , Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W Hunter, Sophia Y Lunt, Thomas G P Grünewald, Sarah-Maria Fendt - 2021 - Molecular Cell - Pubmed

2020

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy - Sarah-Maria Fendt, Christian Frezza and Ayelet Erez - 2020 - CANCER DISCOVERY - Pubmed

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1 - Christensen, Emily M.; Bogner, Alexandra N.; Vandekeere, Anke; Tam, Gabriela S.; Patel, Sagar M.; Becker, Donald F.; Fendt, Sarah-Maria; Tanner, John J. - 2020 - Journal of Biological Chemistry - Pubmed

Nutrient metabolism and cancer in the in vivo context: A metabolic game of give and take - Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt - 2020 - EMBO reports - Pubmed

Cancer cells stock up in lymph vessels to survive - Barbara M Grüner, Sarah-Maria Fendt - 2020 - NATURE - Pubmed

Age-induced accumulation of methylmalonic acid promotes tumour progression - Gomes, Ana P.; Ilter, Didem; Low, Vivien; Endress, Jennifer E.; Fernandez-Garcia, Juan; Rosenzweig, Adam; Schild, Tanya; Broekaert, Dorien; Ahmed, Adnan; Planque, Melanie; Elia, Ilaria; Han, Julie; Kinzig, Charles; Mullarky, Edouard; Mutvei, Anders P.; Asara, John; de Cabo, Rafael; Cantley, Lewis C.; Dephoure, Noah; Fendt, Sarah-Maria; Blenis, John - 2020 - NATURE - Pubmed

Pyrvinium pamoate induces death of triple-negative breast cancer stem-like cells and reduces metastases through effects on lipid anabolism. - Dattilo, Rosanna; Mottini, Carla; Camera, Emanuela; Lamolinara, Alessia; Auslander, Noam; Doglioni, Ginevra; Muscolini, Michela; Tang, Wei; Planque, Melanie; Ercolani, Cristiana; Buglioni, Simonetta; Manni, Isabella; Trisciuoglio, Daniela; Boe, Alessandra; Grande, Sveva; Luciani, Anna Maria; Iezzi, Manuela; Ciliberto, Gennaro; Ambs, Stefan; De Maria, Ruggero; Fendt, Sarah-Maria; Ruppin, Eytan; Cardone, Luca - 2020 - Cancer research - Pubmed

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis - Mouna Triki, Gianmarco Rinaldi, Melanie Planque, Dorien Broekaert, Alina M Winkelkotte, Carina R Maier, Sudha Janaki Raman, Anke Vandekeere, Joke Van Elsen, Martin F Orth, Thomas G P Grünewald, Almut Schulze, Sarah-Maria Fendt - 2020 - Cell Rep - Pubmed

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization - Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, Roberto Gianni-Barrera, Evi Masschelein, Gommaar D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, Tong Tong Wang, Mélanie Planque, Peter Carmeliet, Luc Pellerin, Christian Wolfrum, Sarah-Maria Fendt, Andrea Banfi, Christian Stockmann, Inés Soro-Arnáiz, Manfred Kopf, Katrien De Bock - 2020 - Cell Metabolism - Pubmed