Selected Publications

Translational Genetics

2020

DNA Methylation-Driven EMT Is a Common Mechanism of Resistance to Various Therapeutic Agents in Cancer. - Galle, E., B. Thienpont, S. Cappuyns, T. Venken, P. Busschaert, M. Van Haele, E. Van Cutsem, T. Roskams, J. van Pelt, C. Verslype, J. Dekervel and D. Lambrechts. - 2020 - CLINICAL EPIGENETICS - Pubmed

2019

The genomic landscape of nonsmall cell lung carcinoma in never smokers. - Boeckx, B., R.B. Shahi, D. Smeets, S. De Brakeleer, L. Decoster, T. Van Brussel, D. Galdermans, P. Vercauter, L. Decoster, P. Alexander, G. Berchem, S. Ocak, P. Vuylsteke, K. Deschepper, M. Lambrechts, N. Cappoen, E. Teugels, D. Lambrechts, J. De Greve. - 2019 - INTERNATIONAL JOURNAL OF CANCER - Pubmed

Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis. - Heylen, L., Thienpont, B., Busschaert, P., Sprangers, B., Kuypers, D., Moisse, M., Lerut, E., Lambrechts, D., Naesens, M. Kidney Int - 2019 - KIDNEY INTERNATIONAL - Pubmed

Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration. - Balikova I, Postelmans L, Pasteels B, Coquelet P, Catherine J, Efendic A, Hosoda Y, Miyake M, Yamashiro K; ANGEL study group members, Thienpont B, Lambrechts D - 2019 - BMJ OPEN OPHTHALMOLOGY - Pubmed

2018

Phenotype molding of stromal cells in the lung tumor microenvironment. - Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, Weynand B, Verbeken E, De Leyn P, Liston A, Vansteenkiste J, Carmeliet P, Aerts S, Thienpont B. - 2018 - Nat Med - PubMed

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. - Smeets D, Miller IS, O'Connor DP, Das S, Moran B, Boeckx B, Gaiser T, Betge J, Barat A, Klinger R, van Grieken NCT, Cremolini C, Prenen H, Mazzone M, Depreeuw J, Bacon O, Fender B, Brady J, Hennessy BT, McNamara DA, Kay E, Verheul HM, Maarten N, Gallagher WM, Murphy V, Prehn JHM, Koopman M, Punt CJA, Loupakis F, Ebert MPA, Ylstra B, Lambrechts D, Byrne AT. - 2018 - Nat Commun - PubMed

2017

Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations. - Brown D, Smeets D, Székely B, Larsimont D, A Szász M, Adnet P-Y, Rothé F, Rouas G, Nagy ZI, Faragó Z, Tőkés A-M, Dank M, Szentmártoni G, Udvarhelyi N, Zoppoli G, Pusztai L, Piccart M, Kulka J, Lambrechts D, Sotiriou C, Desmedt C - 2017 - Nat Commun. - PubMed

The role of fatty acid Beta-oxidation in lymphangiogenesis. - Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Bruning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt S-M, Luttun A, Noël A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P. - 2017 - Nature - PubMed

2016

Tumour hypoxia causes DNA hypermethylation by reducing TET activity. - Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Koh KPeng, Mazzone M, Coleman ML, Carell T, Carmeliet P, Lambrechts D. - 2016 - Nature - PubMed

HIF-1alpha Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival. - Stegen S, Van Gastel N, Eelen G, Ghesquière B, D'Anna F, Thienpont B, Gouveia J, Torrekens S, Van Looveren R, Luyten FP, Maxwell PH, Wielockx B, Lambrechts D, Fendt S-M, Carmeliet P, Carmeliet G. - 2016 - Cell Metab - PubMed