Selected Publications

Translational Genetics

2020

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling. - Qian J, Olbrecht S, Boeckx B, Vos H, Laoui D, Etlioglu E, Wauters E, Pomella V, Verbandt S, Busschaert P, Bassez A, Franken A, Bempt MV, Xiong J, Weynand B, van Herck Y, Antoranz A, Bosisio FM, Thienpont B, Floris G, Vergote I, Smeets A, Tejpar S, Lambrechts D. - 2020 - CELL RESEARCH - Pubmed

DNA Methylation-Driven EMT Is a Common Mechanism of Resistance to Various Therapeutic Agents in Cancer. - Galle E, Thienpont B, Cappuyns S, Venken T, Busschaert P, Van Haele M, Van Cutsem E, Roskams T, van Pelt J, Verslype C, Dekervel J and Lambrechts D. - 2020 - CLINICAL EPIGENETICS - Pubmed

DNA methylation repels binding of HIF transcription 1 factors to maintain tumour immunotolerance (accepted) - D’Anna F, Van Dyck L, Xiong J, Zhao H, Berrens R, De Smedt J, Bieniasz-Krzywiec P, Chandra V, Schoonkans L, Matthews J, Minnoye L, Qian J, Amorim R, Khorasanizadeh S, De Borre M, Savvides S, Simon C, Carmeliet P, Reik W, Rastinjad F,Mazzone M, Thienpont B, Lambrechts D - 2020 - Genome Biology -

Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages (submitted) - Wauters E, Van Mol P, Garg AD, Jansen S, Van Herck Y, Vanderbeke L, Bassez A, Boeckx B, Malengier-Devlies B, Timmerman A, Van Brussel T, Van Buyten T, Schepers R, Heylen E, Dauwe D, Dooms C, Gunst J, Hermans G, Meersseman P, Testelmans D, Yserbyt J, Matthys P, Tejpar S, CONTAGIOUS collaborators, Neyts J, Wauters J, Qian J, Lambrechts D - 2020 - -

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity (submitted) - Vanderbeke L, Van Mol P, Van Herck Y, De Smet F, Humblet-Baron S et. al, Lambrechts D - 2020 - -

A Single-cell Map of the Dynamic Changes during Immune-checkpoint Blockade in Early Breast Cancer (submitted) - Bassez A, Vos H, Van Dyck L, Floris G, Desmedt C, Boeckx B, Arijs I, Vanden Bempt M, Nevelsteen I, Lambein K, Punie K, Neven P, Garg AD, Wildiers H, Qian J, Smeets A, Lambrechts D - 2020 - -

2019

The genomic landscape of nonsmall cell lung carcinoma in never smokers. - Boeckx B, Shahi RB, Smeets D, De Brakeleer S, Decoster L, Van Brussel T, Galdermans D, Vercauter P, Decoster L, Alexander P, Berchem G, Ocak S, Vuylsteke P, Deschepper K, Lambrechts M, Cappoen N, Teugels E, Lambrechts D, De Greve J. - 2019 - INTERNATIONAL JOURNAL OF CANCER - Pubmed

Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis. - Heylen L, Thienpont B, Busschaert P, Sprangers B, Kuypers D, Moisse M, Lerut E, Lambrechts D, Naesens M. - 2019 - KIDNEY INTERNATIONAL - Pubmed

Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration. - Balikova I, Postelmans L, Pasteels B, Coquelet P, Catherine J, Efendic A, Hosoda Y, Miyake M, Yamashiro K; ANGEL study group members, Thienpont B, Lambrechts D - 2019 - BMJ OPEN OPHTHALMOLOGY - Pubmed

2018

Phenotype molding of stromal cells in the lung tumor microenvironment. - Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, Weynand B, Verbeken E, De Leyn P, Liston A, Vansteenkiste J, Carmeliet P, Aerts S, Thienpont B. - 2018 - Nat Med - PubMed